Rosácea: Análise e Comentários

Abstract

Rosacea is a chronic inflammatory disease, predominant in populations with low phototypes and women. It has a multifactorial presentation, such as immunobiological alterations, neurovascular dysregulation, presence of cutaneous microorganisms, ultraviolet (UV) damage and dysfunction of the cutaneous barrier, responsible for the clinical manifestations of the skin. Abundant cell types have been implicated in rosacea, including keratinocytes, mast cells, endothelial cells, macrophages, fibroblasts, and Th1/Th17 cells. We know that LL-37 causes erythema, flushing and telangiectasias. This protein influences the activity of mast cells, which promote the inflammatory state of the disease. Lesions on the face do not appear abruptly, they start mainly with central facial erythema and may have other characteristics, such as phymatous changes, flushing, papules and pustules, telangiectasias, eye changes, burning and burning of the skin, edema and skin dryness , between others.