Use of tranexamic acid in the treatment of melasma.

Abstract

Melasma is a chronic hypermelanosis caused by patches of various shades, caused by solar radiation, hormonal and vascular factors, genetic predispositions, etc. Tranexamic acid stands out as a possible effective treatment to prevent or reduce the area affected by Melasma. This review discusses the effects caused by the use of tranexamic acid in the treatment of Melasma, as well as understanding the working mechanisms, possible indications and adverse effects. A literature review was carried out using the PubMed, SciELO and Google Scholar platforms as a research source, in order to search for academic works published from 2012 to 2022 on a topic of interest. Tranexamic acid is a hydrophilic plasmin inhibitor drug, which uses antifibrinolytic agent to treat melasma. Of the various forms of application presented, oral use stands out as the most efficient and safe, bringing fewer side effects. In view of this, it is possible to state that the use of tranexamic acid in the treatment of melasma is effective and safe, without significant side effects.