Dupilumabe como alternativa no tratamento da dermatite atópica em crianças e adolescentes

Abstract

Atopic dermatitis (AD) is an inflammatory and chronic dermatological condition that mainly affects children and adolescents. AD significantly impacts the quality of life of patients, affecting the quality of sleep, generating irritability, stress and also implying a significant expense with treatments. This literature review analyzed the most recent findings on the application of dupilumab as an alternative in the treatment of AD in children and adolescents. The filters in the PubMed database were applied: randomized clinical trials; published in English; full text available for free access and published from 2020 that used dupilumab in the treatment of AD in children and adolescents. Of the 21 results, 7 articles were selected for analysis. Dupilumab is an alternative for the treatment of AD in children and adolescents, with adverse effects that do not imply treatment discontinuation, with an acceptable safety profile and results similar to those obtained in adults. It is concluded that dupilumab is effective and safe for the treatment of AD in children and adolescents.