Síndrome de Sweet

Abstract

Sweet’s syndrome is a rare neutrophilic dermatosis, described by Robert Douglas Sweet in 1964, it is manifested by painful erythematous plaques, associated with fever and neutrophilic infiltrate in histopathology. It is currently classified into classical, associated with malignancy, and drug-induced form. The objective is to present two cases treated on dermatology clinic of Faculdades BWS, with typical presentation of the disease and their terapeutic challanges. Male, 68 years old, previously treated for leprosy, and a 44 years old female, with lesions that started after a flu. A significant improvement in the skin lesions was observed with the use of Prednisone at doses between 0,5-1 mg/kg/day, but in one of the patients new lesions appeared after tapering the medication, requiring the introdution of Colchicine and further investigation, and after Adalimumab. The present case report showed a satisfactory clinical response to first-line treatment, but new approches should be evaluated in refractary cases.